20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP1453 | Tau protein (592-597), Human TFA | Others | |
Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein. | |||
TP1420 | Microtubule-associated protein tau (26-44) | ||
Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine. | |||
T79038 | Tau protein aggregation-IN-1 | ||
Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Hunt... | |||
T81031 | tau protein/α-synuclein-IN-1 | ||
Tau protein/α-synuclein-IN-1 is a dual inhibitor that not only impedes tau protein and α-synuclein but also reduces the development of α-syn inclusions in M17D neuroblastoma cells, making it a useful agent in the study o... | |||
T9611 | PF-04802367 | GSK-3 | |
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ... | |||
T22118 | NQTrp | Microtubule Associated | |
NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. | |||
T14046 | Anandamide | (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | Cannabinoid Receptor , Endogenous Metabolite |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... | |||
T67834 | C004019 | Microtubule Associated , PROTACs | |
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C... | |||
T62899 | Tau-aggregation and neuroinflammation-IN-1 | Microtubule Associated , NO Synthase | |
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma... | |||
T76726 | Zagotenemab | LY33003560 | Microtubule Associated |
Zagotenemab is a humanized antibody against the microtubule-associated protein tau that selectively regulates tau deposits in the brain. Zagotenemab can be used to study neurological disorders such as Alzheimer's disease... | |||
T61661 | LY3372689 | Formulaic Ia | Microtubule Associated |
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease. | |||
T37621 | Ezeprogind disulfate | Beta Amyloid | |
Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind disulfate can be used for the research of neurological disor... | |||
T61360 | ARN25068 | GSK-3 , DYRK , Microtubule Associated , Src | |
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1]. | |||
T77342 | GSK-3 inhibitor 3 | GSK-3 , Microtubule Associated | |
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... | |||
T7003 | Leucomethylene blue mesylate | TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate | Beta Amyloid , Microtubule Associated |
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. | |||
T77341 | GSK-3 inhibitor 4 | GSK-3 , CDK | |
GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with IC50 values of 0.56 nM, 0.45 nM, 0.47 μM, 0.68 μM, respect... | |||
T111959 | IFB-088 acetate | ||
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... | |||
T30438 | BF-158 | ||
BF-158 is used for imaging tau protein. | |||
T40409 | Tau Peptide (275-305) (Repeat 2 domain) | ||
Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining ... | |||
T76652 | PHF6 | ||
PHF6 (VQIVYK), a sequence within the third microtubule-binding repeat region of the tau protein, initiates the aggregation of the full-length tau protein through its self-assembly capabilities [1]. |